Quantitative phase imaging (QPI) provided by Q-PHASE, a TESCAN multimodal holographic microscope, allows precise detection and quantification of changes in cell dry mass and related morphological parameters specific to cell death. Thus, individual phases of cell death can be easily distinguished based on the monitoring of a single cell behavior over time. Using the Q-PHASE, significant changes of cellular parameters have been detected in human prostate adenocarcinoma LNCaP cells treated with a chemotherapy drug doxorubicin (DOX).
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