TESCAN GAIA3 FIB-SEM for Research in Nanomedicine

Intertwining DNA-RNA nanocapsules loaded with tumor neoantigens as synergistic nanovaccines for cancer immunotherapy
Self-assembled intertwining DNA-RNA nanocapsules (iDR-NCs) represent a general technology to construct hybrid DNA-RNA nanostructures that can be further loaded with hydrophobic peptide therapeutics. The iDR-NCs developed in this work served as potent synergistic nanovaccines for personalized combination cancer immunotherapy. The TESCAN GAIA3 Ga Focused Ion Beam Scanning Electron Microscope was used to prepare and image cross-sections of iDR-NCs which allowed studying their internal structure.

Link: https://www.nature.com/articles/s41467-017-01386-7

SEM images showing iDR-NCs before and after FIB. FIB exposed the interior hollow structures of NCs. Scale bar: 500 nm.

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