Electron microscopy plays an integral role in research and development of new drug formulations. Structure, particle size, porosity and presence of contaminants have been responsible for the final activity of the drug.
TESCAN SEMs offer very high resolution imaging and superb analytical performance, which make them perfect and reliable tools for quality control of new preparations.
  • Our dedicated EasySEM and EasyEDX software options transform our system in an easy to use instrument for routine quality control.
  • Nowadays, a lot of research effort has been devoted to the development of sophisticated drug micro- and nano-carriers for controlled release and targeted delivery.
  • These substances are often based on polymer chemistry, which are often sensitive to the electron beam.
  • For these purposes, the TESCAN MAIA3 FEG-SEM provides the highest resolution imaging even at low accelerating voltages.
  • For samples that cannot be prepared using standard methods or sputter coated with metals, users can take advantage of the variable pressure mode UniVac.
  • Using the Peltier cooling stage and Water Vapor Inlet System researchers can monitor dynamic processes such as crystallization or dissolution of the substance.
Structure of a drug powder

Related Application Notes

Low temperature scanning electron microscopy for Life Sciences
Low temperature scanning electron microscopy (Cryo-SEM) has become an established technique for capturing and observing biological samples close to their natural state. It is a method of choice, where the traditional sample preparation (e.g. critical point drying) causes unwanted changes in the sample structure. A Cryo-SEM workflow typically involves sample fixation using either flash-freezing in a liquid nitrogen slush or high-pressure freezing. The frozen samples are then transferred under vacuum to a cryo sputter coater, where they are coated with a conductive layer of metals or carbon. Finally, the samples are inserted into a SEM chamber equipped with a cryo-stage and observed in high vacuum environment.
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