WEBINAR | Up to 40% Faster Automated TEM Lamella Preparation with new Ga⁺ FIB Column

Preserve Native Biological Structure for Reliable Cryo-ET and Volume Electron Microscopy

Achieving reproducible cryo-ET data starts with precise sample preparation and preserved structural integrity. Tescan solutions deliver cryogenic FIB-SEM workflows that maintain native cell and tissue morphology. This enables confident cryo-lamella preparation, high-resolution surface imaging, and 3D volume reconstruction in life-science research.

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TESCAN SOLUTIONS

FOR THE ENTIRE LIFE SCIENCES RESEARCH AND DEVELOPMENT PROCESS
Cryo-ET Sample Preparation

Cryo-electron microscopy (cryo-EM) has revolutionized structural biology. By enabling the observation of cellular structures in their near-native state at molecular resolution, this groundbreaking technology is reshaping how scientists understand life at the nanoscale. Whether preparing thin lamellae for Cryo-Electron Tomography (Cryo-ET) to obtain the finest structural details or performing Cryogenic volume imaging, Tescan workflows ensure precision, reliability, and sample integrity throughout the entire process. 

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Surface Morphology Analysis

Enable reproducible results and reveal delicate biological structures for reliable surface morphology studies. Tescan workflows provide detailed, high-contrast imaging of coated, uncoated, and hydrated samples, revealing essential topographical features that drive discovery in the life sciences. 

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Volume Electron Microscopy

Understanding biological systems requires more than a single plane of imaging—how organelles interact within cells, how cells organize in tissues, or how microbial communities form in ecological niches. Tescan volume electron microscopy (vEM) provides multi-scale, 3D insights into cells, tissues, and small organisms. 

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"Tescan AMBER X 2, our latest innovation in materials analysis technology. The AMBER X 2, with its advanced Plasma FIB-SEM capabilities, offers unmatched speed, precision, and versatility, setting a new standard in the field."

PETR KLIMEK
Product Marketing Director Material & Geo Science
Tescan

Quote-Petr-Klimek

Tescan Instruments & Technology

Used in This Workflow

Tescan AMBER G

TESCAN AMBER G™ is a cryogenic Ga FIB-SEM workstation for Life Sciences research. This enables precise cryo-lamella preparation, surface morphology analysis, and 3D volume electron microscopy under stable cryo conditions.

Its field-free UHR SEM column and integrated cryo-stage preserve native cellular architecture and deliver reproducible nanoscale imaging across biological samples.

  • Cryogenic FIB-SEM: site-specific thinning of vitrified cells and tissues for cryo-ET and cryo-TEM
  • Structural preservation: controlled cryo-environment prevents devitrification and ice contamination during milling and imaging
  • Integrated workflows: automated slice-and-view and correlative light-electron imaging for reliable 3D reconstruction

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