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Preserve Native Biological Structure for Reliable Cryo-ET and Volume Electron Microscopy

Achieving reproducible cryo-ET data starts with precise sample preparation and preserved structural integrity. Tescan solutions deliver cryogenic FIB-SEM workflows that maintain native cell and tissue morphology. This enables confident cryo-lamella preparation, high-resolution surface imaging, and 3D volume reconstruction in life-science research.

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TESCAN SOLUTIONS

FOR THE ENTIRE LIFE SCIENCES RESEARCH AND DEVELOPMENT PROCESS
Cryo-ET Sample Preparation

Cryo-electron microscopy (cryo-EM) has revolutionized structural biology. By enabling the observation of cellular structures in their near-native state at molecular resolution, this groundbreaking technology is reshaping how scientists understand life at the nanoscale. Whether preparing thin lamellae for Cryo-Electron Tomography (Cryo-ET) to obtain the finest structural details or performing Cryogenic volume imaging, Tescan workflows ensure precision, reliability, and sample integrity throughout the entire process. 

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Surface Morphology Analysis

Enable reproducible results and reveal delicate biological structures for reliable surface morphology studies. Tescan workflows provide detailed, high-contrast imaging of coated, uncoated, and hydrated samples, revealing essential topographical features that drive discovery in the life sciences. 

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Volume Electron Microscopy

Understanding biological systems requires more than a single plane of imaging—how organelles interact within cells, how cells organize in tissues, or how microbial communities form in ecological niches. Tescan volume electron microscopy (vEM) provides multi-scale, 3D insights into cells, tissues, and small organisms. 

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"Tescan AMBER X 2, our latest innovation in materials analysis technology. The AMBER X 2, with its advanced Plasma FIB-SEM capabilities, offers unmatched speed, precision, and versatility, setting a new standard in the field."

PETR KLIMEK
Product Marketing Director Material & Geo Science
Tescan

Quote-Petr-Klimek

Tescan Instruments & Technology

Used in This Workflow

Tescan CLARA

Tescan CLARA is engineered for advanced biological imaging under both ambient and cryogenic conditions. It supports a wide range of workflows, enabling researchers to capture complex biological structures and visualize them in 2D and 3D with exceptional detail. 

  • BrightBeam™ technology delivers ultra-high resolution and sharp, contrasted images even at very low beam energies. 

  • In-Flight™ beam tracing and automated alignments enable users to optimize imaging and analysis quickly and consistently. 

  • Wide Field Optics™ allows distortion-free navigation from 1× overview down to nanoscale features 

  • MultiVac™ Imaging Mode automates low-vacuum aperture and water-vapor operation for imaging of sensitive samples. 

  • TESCAN Essence™ interface ensures effortless operation and multi-user support for streamlined operation across all experience levels.



Tescan AMBER 2

Tescan AMBER 2 is a cryogenic Ga+ FIB-SEM workstation for Life Sciences research. This enables precise cryo-lamella preparation, surface morphology analysis, and 3D volume electron microscopy under stable cryo conditions.

Its field-free UHR SEM column and integrated cryo-stage preserve native cellular architecture and deliver reproducible nanoscale imaging across biological samples.

  • Cryogenic FIB-SEM: site-specific thinning of vitrified cells and tissues for cryo-ET and cryo-TEM
  • Structural preservation: controlled cryo-environment prevents devitrification and ice contamination during milling and imaging
  • Integrated workflows: automated slice-and-view and correlative light-electron imaging for reliable 3D reconstruction

Tescan AMBER X 2

High-performance plasma FIB-SEM system designed for demanding cryo and room temperature structural analysis.

  • 3D FIB-SEM tomography of large volumes and/or hard materials such as shells, bones, and dental tissue 

  • Superior quality cryo lamella preparation with MISTRAL™ Plasma FIB for fast rough milling and precise low-energy polishing 

  • Integrated CLEM: Precise ROI targeting with integrated METEOR 2.0 

  • Built-in Tescan Cryo-Nanomanipulator: Temperature-controlled system for safe and efficient cryo lift-out 

  • Integrated Leica/Quorum cryo workflow

The Tescan AMBER X 2 uses plasma FIB milling to enable high-throughput structural analysis under ambient and cryogenic conditions, offering speed and efficiency. It delivers reliable, artefact-free results for advanced life science research, from large-volume 3D tomography of hard biological materials to high-quality cryo lamella preparation.

Tescan SOLARIS 2

Advanced analytical tool for 2D and 3D characterization of your biological ​and beam-sensitive samples​. It combines Ga FIB with immersion optics.

  • Low-keV, high-contrast BSE imaging – Reveal resin-embedded biological structures in 2D and 3D with exceptional clarity. 

  • UHR-SEM Immersion Optics – Provides detailed imaging for challenging biological samples, ensuring accurate observation of delicate ultrastructures. 

  • Best resolution Ga+ FIB column (< 2.5 nm resolution) with optimized ion optics for excellent performance and reproducibility 

  • Tescan Essence™ Software: Designed for multi-user environments, ensuring effortless operation regardless of experience level.   

Designed for precision and flexibility, SOLARIS 2 brings together low-keV, high-contrast imaging with advanced analytical and correlative workflow to clearly visualize biological ultrastructure in 2D and 3D.

 

 

Tescan SOLARIS X 2

Tescan SOLARIS X 2 combines MISTRAL™ Xe plasma FIB with UHR-SEM immersion optics for precise lamella preparation and high-quality cryo imaging. Its enhanced beam profile enables fast milling and low-energy polishing, ideal for large-volume and high-throughput cryo workflows.   

  • MISTRAL™ Xe Plasma FIB Column: Enhanced beam profile for fast milling and precise low-energy polishing.  

  • UHR-SEM Immersion Optics: Optimized for high-quality cryo imaging.  

  • Built-in Tescan Cryo-Nanomanipulator: Temperature-controlled system for safe and efficient lamella lift-out 

  • Integrated CLEM: Precise ROI targeting with integrated METEOR 2.0 

  • Tescan Essence™ Software: Designed for multi-user environments, ensuring effortless operation regardless of experience level.  

  • Integrated Leica/Quorum cryo workflow

The SOLARIS X 2 offers both cryo-stable performance and intuitive navigation, ensuring consistent and reproducible results, even in the most demanding applications.

 

 

 

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Tescan
Libušina třída 21
623 00 Brno
Czech Republic

130405923 us US 37.09024 -95.712891 25.3575 29.349345 20.67957527 42.082797 39.91384763 -33.693421 13.93320106 3.039986586 31.997988 38.050985 47.579533 48.1485965 58.375799 54.663142 19.195447 56.975106 50.493053 45.868592 10.79556993 44.35660598 43.2371604 55.536415 14.557577179752773 32.100937 -6.116829 -6.212299277967318 23.7104 -33.471062 31.998740087 -23.69149395 43.462349 51.529848 49.1893523 49.197486 25.072375 31.075811 1.299027 40.676979 52.30150662 51.013813 35.684121 37.479653 52.246622 40.581349 39.911632 -26.1811371 41.818215 33.429928

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