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Structural Biology

Biomedical engineering is one of the fastest-growing research areas. It combines the latest concepts from medicine, biotechnology and engineering for designing a variety of technologies such as support matrices for cell growth, artificial tissue and implantable biomedical devices.

Life Sciences

Structural Biology

The structural subcellular analysis provides information hidden under the surface of cells and tissue. Typically this area of research has been a domain of transmission electron microscopy. However, SEM technology is becoming more popular in this field, due to emerging techniques available with scanning electron microscopy solutions. TESCAN offers several solutions for scientists interested in the subcellular investigations of biological samples.

STEM Image of cyanobacteria

STEM Image of cyanobacteria

  • The first approach involves the incorporation of a removable STEM detector inside the SEM chamber, thus transforming any TESCAN SEM into a low-kV TEM instrument.
  • STEM detector is fully compatible with standard grids routinely used in TEM microscopes.
  • Another approach uses serial sectioning inside the SEM instrument followed by imaging. The sectioning can be done either by implementing an ultramicrotome inside the chamber or directly by focused ion beam technology.
  • By serial sectioning of the samples followed by subsequent segmentation and rendering, researchers can easily visualize the relevant data in 3D.

 

 

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    3D micro-CT analysis of a sheep femur

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Do you wish to discuss Structural Biology applications? Contact our Team directly!